Advanced hepatocellular carcinoma refractory to conventional transarterial chemoembolization (cTACE): treatment with sorafenib alone or sorafenib combined with drug-eluting beads transarterial chemoembolization (DEB-TACE)

This submission has open access
Submission ID :
GEST2021-72
Submission Type
Submission Topic
Sub-topics
Non-IO
Purpose :
We sought to investigate the effectiveness of drug-eluting beads transarterial chemoembolization (DEB-TACE) combined with sorafenib for salvage therapy in patients with advanced hepatocellular carcinoma (HCC) refractory to conventional transarterial chemoembolization (cTACE).
Materials & Methods :
This retrospective study was approved by the ethics committee governing five tertiary medical centers in China. Between January 2016 and January 2018, 144 consecutive patients with advanced cTACE-refractory HCC received either DEB-TACE combined with sorafenib (dTS group, n=63) or sorafenib alone (S group, n=81). The adverse events (AEs), disease control rate (DCR), overall survival (OS), and time to progression (TTP) were compared between the two groups.
Results :
The baseline characteristics and AEs of patients in both groups were similar. The post-treatment DCR was significantly higher in the dTS group than in the S group (81% vs. 55.6%; P=0.003). The median OS was significantly longer in the dTS group than in the S group (13.7 vs. 7.7 months; P< 0.001), as was the TTP (7.7 vs 3.0 months; P< 0.001). Multivariate analysis showed that alpha-fetoprotein level, intrahepatic tumor number, tumor size, portal vein invasion, arterioportal shunts, and treatment allocation were significant predictors of OS and TTP.
Conclusions :
DEB-TACE combined with sorafenib is well tolerated, safe, and superior to sorafenib alone in terms of improving survival in patients with advanced HCC refractory to cTACE.

Associated Sessions

The First Affiliated Hospital of Sun Yat-Sen University

Similar Abstracts by Type

Submission ID
Submission Title
Submission Topic
Submission Type
Primary Author
GEST2021-40
Ablation
Live - Oral Presentation
Shamar Young
GEST2021-85
Liver
Live - Oral Presentation
Mr. Courtney Henry
GEST2021-172
Live - Oral Presentation
Research Committee
GEST2021-173
Live - Oral Presentation
Research Committee
GEST2021-174
Live - Oral Presentation
Research Committee
GEST2021-175
Live - Oral Presentation
Research Committee
45 hits